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Formula 9 Great Value!
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60 Capsule Bottle
15-30 Day Supply
(using 2-4 daily)
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A new natural compound that offers substantial
benefits for overweight consumers. This patented plant extract
is found exclusively in Formula
9, along with a proprietary mixture of additional energy- and
weight-loss promoting ingredients... which have been specifically
formulated to deliver an entirely new breed of powerful and
effective ergogenic diet aids.
The Study: Patented Plant Extract Induces Weight Loss and
Increases the Lean to Fat Mass Ratio in Humans
Central to the effectiveness of Formula 9 is the presence
of the new weight-loss agent. In a recent randomized, double-blind,
placebo-controlled trial, 50 volunteers with a Body Mass Index
(BMI) over 25 (moderately to severely obese) were randomized
to two groups receiving either placebo capsules or a capsules
containing 200 mg of the novel standardized extract (called
CAE) found in Formula 9. Each volunteer took one capsule with
each main meal, two a day, for 60 days. All subjects were instructed
to follow a lowcalorie diet plan and not to change any of their
physical activities. At the end of the 60- day study, the treatment
group experienced a mean reduction in weight of about 11 pounds
(5.7%) that was highly statistically different from the smaller
weight reduction experienced by the placebo group (only 5.4
pounds (2.9%)(p<0.00001). Consequently, the BMI decreased
significantly in the experimental CAE group compared to the
placebo group. Moreover, the muscle mass/fat mass ratio increased
significantly in the treatment group compared to the control
group: 2.03 (4%) vs. 0.6 (1.5%) respectively (p<0.013).
The sizeable decrease of body weight, BMI, and fat mass observed
in the treatment group demonstrates that the Formula 9 CAE
is able to significantly intensify weight loss in a group of
volunteers ingesting a low-caloric diet. (The object of the
lowcaloric diet was to lower the carbohydrate load, which would
account for the modest weight loss seen in the placebo group.)
The additional, substantial weight loss is postulated to be
due to the ability of CAE to inhibit both glucose absorption
and the activity of the enzyme glucose-6-phosphatase. The latter
activity would limit the release of glucose into the general
circulation and therefore limit insulinemia, which would in
turn limit fat storage and new body fat formation and lead
to utilization of the fat reserves for energy.
How CAE Works
Proper glucose metabolism is fundamental to effective weight
management. Maintaining a normal blood glucose concentration
is a finely balanced equilibrium between food intake, energy
expenditure and the mechanisms by which glucose is stored or,
is released into the blood. The human clinical study using
the standardized, highly purified CAE targeted weight loss
via an activity on postprandial blood glucose concentration
(PBGC). PBGC is the fancy term referring to the amount of sugar
remaining in your blood after eating a meal (the italicized
terms are synonymous). This figure varies according to the
composition of the meal but in every case is accompanied by
an increase in the secretion of insulin and a decrease in the
synthesis of glucagon. This hormonal activity results in the
decrease of blood sugar by increasing its storage as glycogen
in the liver or muscles (and in the form of fat (triglycerides)
in fat cells, if glycogen storage areas fill up). This is called
the 'absorption phase,' as the sugar is being absorbed from
Over time (toward the end of the absorption phase or when
fasting), the plasma glucose level decreases and reversal of
the hormonal regulation occurs such that insulin levels drop
and the secretion of glucagon increases. This activity results
in the release of muscle glycogen for use as energy. High levels
of glucagon will act to produce fatty acids from stored fat.
The Role of Chlorogenic Acid in CAE
Chlorogenic acids are a group of esters of varying composition.
The most common of these esters is 5-caffeoylquinic acid. It
is commonly called "chlorogenic acid" in research
papers, but this term may also be used to refer to other esters
in the mix found in CAE. Hence, for the sake of simplicity,
the term chlorogenic acid (CA) will be used in this paper as
a generic term for all members of the ester group.
If the results of the study are indicative, the presence of
CA in the CAE increased the effectiveness of reduced GI by
a significant margin. This was not an unexpected outcome. Rather,
it was a reasonable and predicted result, based on the observations
of a number of scientific papers describing the action of CA
on a number of related parameters. One of the most important
of those actions is a postprandial reduction in the absorption
of glucose from the intestines. Decreased glucose absorption
means less excess glucose in the blood, an eventual decrease
in insulin resistance, a propensity for greater fat burning
activity in liver and muscle cells, reduced fat storage and
loss of body weight. The specific mode of action is an inhibitory
effect on the sodium ion electrochemical gradient which draws
glucose into the cells (enterocytes) lining the gut. This appears
to be a dose-dependant phenomenon (in rats the effect has been
as high as 80%). In a human study it was found that CA significantly
attenuated the postprandial release of GIP (glucose-dependent
insulinotropic polypeptide). The GIP response is directly related
to the amount of glucose absorbed at the intestinal barrier;
hence, a decrease in GIP reflects a decrease in glucose absorption.
Another manner in which CA decreases the blood glucose load
is through the inhibition of an enzyme known as glucose-6-phosphatase
(G6P). G6P plays an important role in the homeostatic control
of blood sugar concentration. Present only in the liver, it
is really an enzyme system and is responsible for the conversion
of glucose-6-phosphate into glucose capable of passing into
the general circulation. Inhibition of G6P causes a reduction
in the liver's production of glucose and consequently decreases
abnormally high levels of glucose in the blood. All sugars
from the diet are transformed into G6P, which will be stored
as glycogen because they cannot be broken down into glucose
and released into the blood by G6P. Animal studies indicate
that CA improves sensitivity to insulin by improving the distribution
of minerals and by reducing peripheral insulin resistance.
To summarize the body of work done on chlorogenic acid, the
following sequence of events will occur following its regular
A reduction in the intestinal absorption of glucose.
Inhibition of glucose-6-phosphatase (G6P).
Inhibition of the release of hepatic glucose originating from:
glycogenolyis (the creation of glucose from glycogen)
gluconeogenesis (the formation of glucose, especially by the
liver, from noncarbohydrate sources, such as amino acids and
the glycerol portion of fats).
Lowering of blood glucose concentration.
A decrease in the secretion of insulin and an increase in the
secretion of glucagon.
Mobilization of fat reserves to supply energy required by muscles
and other tissues.
The burning of free fatty acids for the production of energy
in cellular energy cycles.
An Important Note About CAE Extraction
In order to produce this extract with proven weight-reducing
activity, the raw material must undergo considerable processing.
The desired end result is a product standardized to specific
levels of chlorogenic acids and 5-caffeoylquinic acid. However,
proper, safe CAE extraction requires and additional processing
step: the removal of potentially harmful diterpines. Until
this crucial additional processing step was accomplished (and
we know of only one manufacturing who takes this important
last step), we had not considered CAE suitable for long-term
human consumption. Now that a diterpene-free extract is available,
it has become the major weight-loss component of Formula 9™ and
is exclusive to this product.
NOTE: Any compound that claims to be CAE, but which fails
to remove diterpenes is unsuitable for use in humans.
CAE and Xanthines
Xanthines constitute a family of stimulants that work primarily
through the central nervous system and the sympathetic division
of the peripheral nervous system. They produce a release of
both neurotransmitters and hormones. Two of the most important
of these hormones are adrenaline and noradrenaline, which produce
an almost immediate effect on vigilance and a more sustained
effect on stamina. Xanthines are rapidly absorbed in the intestine
(80%) and the stomach (20%). Because of their lipophilic nature,
they rapidly penetrate cell membranes and easily cross the
A good deal of the research on xanthines has shown that they
exert their ergogenic properties in two ways. First, they energize
the central nervous system, which results in the nearly immediate
increase in mental clarity. Second, and equally important,
they stimulate lipolysis in fat cells, thereby providing cellular
fuel to meet the needs of people involved in prolonged physical
or mental exertion, as is required in a typical day's work
or play output. Lipolysis is the process whereby stored body
fat is converted into forms the body uses for short term and
long term energy production.
Recently, the armed forces of the United States and Canada
have become seriously interested in the possible application
of xanthines as a method for increasing the performance of
soldiers under acute and chronic stress. When people are exposed
to several stressors, mental and physical performance is substantially
degraded. The military was the first to recognize the serious
lack of procedures for counteracting this problem. Astute students
of military history, however, would have noticed that plant
materials containing xanthines have often been used by military
personnel to ward off sleepiness while on guard duty and to
maintain vigilance under combat situations lasting for several
days without relief.
In one of the most rigorous experimental investigations of
the possible role of a trimethylxanthine to offset acute stress,
researchers at the U.S. Army Research Institute of Environmental
Medicine, in conjunction with scientists from Tufts University
and Pennington Biomedical Research Laboratory, examined whether
moderate doses of this xanthine would reduce adverse effects
of sleep deprivation and exposure to severe, multifactor, environmental
and operational stress on mental performance. In this study,
U.S. Navy Sea-Air-Land (SEAL) trainees received either placebo
or xanthine capsules after 3 days of sleep deprivation and
continuous exposure to other stressors, including running,
lifting, paddling, swimming, calisthenics and other rigors
inflicted during the appropriately named "Hell Week" period
As might be expected, sleep loss and exposure to other severe
stressors resulted in a profound deterioration in all aspects
of cognitive function assessed. Measured against placebo, the
xanthine-treated group experienced a significant improvement
in visual vigilance, reaction time, repeated acquisition and
self-reported fatigue and sleepiness, with the greatest effects
on vigilance, reaction time and alertness. Interestingly, marksmanship,
a task that could be affected by shakiness or jitteriness,
was not affected by xanthine. The researchers concluded that
even under the most adverse conditions, moderate doses of xanthine
can improve cognitive function, including vigilance, learning,
memory and mood state.
Other studies have yielded similar results. For example, in
a study carried out under the Defense R&D of Canada, a
group of civilian and military personnel were enlisted in a
trial to examine the duration of xanthine's ergogenic effect
and whether it differs between users and non-users of the substance.
In this trial, patients were required to ride to exhaustion
on a stationary bicycle, following consumption of 5 mg/kg of
trimethylxanthine. In the end, the compound allowed the subjects
to exercise for about 1/2 hour longer, and the non-users benefited
slightly more than the users (about 5 minutes). Not only the
duration but the magnitude of response was greater. The energizing
effect achieved through xanthine ingestion has been demonstrated
in several other studies.
As mentioned above, xanthines exert two primary actions that
can account for the observed enhancement of mental and physical
performance. First, xanthines are universally recognized for
their ability to augment central nervous system function. This
probably accounts for much of the immediate effect on mental
clarity, learning, vigilance, etc. Second, the quick effect
on the nervous system would only be expected to last for a
few minutes in the absence of added fuel in the form of glucose
and, indirectly, from increased free fatty acid concentration
throughout the rest of the body. The extended release of xanthines
in Formula 9™ means that fuel in the form of free fatty
acids will be available throughout the day, thereby helping
to extend for hours the positive effects on mental and physical
Incidentally, the usefulness of xanthines is not restricted
to any particular sex or age group. Indeed, it has been shown
that the elderly experience a decreased ability to mobilize
fat in response to exercise. In this age group, research has
found that xanthines augment fat mobilization as they do in
the young, but to a lesser degree. In other words, the elderly
need all the help they can get, and xanthines should be a great
The presence of modest amounts of xanthine in CAE helps contribute
to its overall beneficial effects in the management of weight.
Formula 9 is improved even further by the addition of xanthines
(primarily in the form of trimethylxanthine) from several plant
Additional Elements of The Formula 9™ Blend
Complementing the patented CAE in Formula 9 is a group of
ingredients designed to enhance the energy and weight-loss
properties of CAE. In particular, additional trimethylxanthine
has been incorporated to provide an even greater energy boost
(see discussion of xanthines above). Other methylxanthines-containing
plants are included to improve the overall xanthine composition
of the product for an even better energy profile. Ingredients
for the modification of so-called cellular second messengers
are included to improve the efficiency of the fat burning (lipolytic)
properties of the plant through the augmentation of catecholamine
Formula 9™: Unsurpassed Weight Control and Energy
Formula 9 is the first of a new breed of energy and weight-control
agents, designed to target overweight concerns where they start,
namely the 2-hour period directly following the consumption
of a meal. Formula 9 is designed to keep the sugar out of the
blood and to prevent fat formation at the earliest possible
In addition, Formula 9 incorporates an extra but very important
component for consumers trying to lose weight. Formula 9 delivers
a significant energy boost to meet the daily energy demands
and encourage fat burning.
The result? Formula 9 is an extremely effective weight-loss,
fat-loss and energy formula that offers consumers a superior
alternative to traditional, last-generation weight control.
Formula 9 does indeed set a new standard.
Formula 9 Product Review
Formula 9 is an extremely effective
weight-loss, fat-loss and energy formula that offers consumers
an alternative to traditional weight
Formula 9 Supplement Info
Other ingredients: Rice flour, magnesium stearate,
cellulose and silicon dioxide.
Directions: Take with a large glass of water, two capsule
with lunch and two capsules with dinner. Not to exceed 2 servings
in any 8-hour period. For a significant energy boost, take
2 capsules anytime needed. Do not exceed 4 capsules per day.
For maximum weight loss, this product should be taken in conjunction
with a healthy eating plan as suggested by the 2005 Dietary
Guidelines for Americans.
Place Your Order for Formula 9
60 Capsule Bottle
15-30 Day Supply
(using 2-4 daily)
4 out of 4 Stars!!!
Order Formula 9 Risk Free!