Formula 9

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Formula 9 60 Capsule Bottle 15-30 Day Supply (using 2-4 daily)	Formula 9 1 Bottle Reg. $39.99 Sale $28.99 Formula 9 2 Bottles Reg. $79.99 Sale $57.99 Formula 9 3 Bottles Reg. $119.99 Sale $83.99 Formula 9 6 Bottles Reg. $239.99 Sale $164.99 Formula 9 12 Bottles Reg. $479.99 Sale $323.88 $26.99 each! Best Value!!

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A new natural compound that offers substantial benefits for overweight consumers. This patented plant extract is found exclusively in Formula 9, along with a proprietary mixture of additional energy- and weight-loss promoting ingredients... which have been specifically formulated to deliver an entirely new breed of powerful and effective ergogenic diet aids.

The Study: Patented Plant Extract Induces Weight Loss and Increases the Lean to Fat Mass Ratio in Humans

Central to the effectiveness of Formula 9 is the presence of the new weight-loss agent. In a recent randomized, double-blind, placebo-controlled trial, 50 volunteers with a Body Mass Index (BMI) over 25 (moderately to severely obese) were randomized to two groups receiving either placebo capsules or a capsules containing 200 mg of the novel standardized extract (called CAE) found in Formula 9. Each volunteer took one capsule with each main meal, two a day, for 60 days. All subjects were instructed to follow a lowcalorie diet plan and not to change any of their physical activities. At the end of the 60- day study, the treatment group experienced a mean reduction in weight of about 11 pounds (5.7%) that was highly statistically different from the smaller weight reduction experienced by the placebo group (only 5.4 pounds (2.9%)(p<0.00001). Consequently, the BMI decreased significantly in the experimental CAE group compared to the placebo group. Moreover, the muscle mass/fat mass ratio increased significantly in the treatment group compared to the control group: 2.03 (4%) vs. 0.6 (1.5%) respectively (p<0.013).

The sizeable decrease of body weight, BMI, and fat mass observed in the treatment group demonstrates that the Formula 9 CAE is able to significantly intensify weight loss in a group of volunteers ingesting a low-caloric diet. (The object of the lowcaloric diet was to lower the carbohydrate load, which would account for the modest weight loss seen in the placebo group.) The additional, substantial weight loss is postulated to be due to the ability of CAE to inhibit both glucose absorption and the activity of the enzyme glucose-6-phosphatase. The latter activity would limit the release of glucose into the general circulation and therefore limit insulinemia, which would in turn limit fat storage and new body fat formation and lead to utilization of the fat reserves for energy.

How CAE Works

Proper glucose metabolism is fundamental to effective weight management. Maintaining a normal blood glucose concentration is a finely balanced equilibrium between food intake, energy expenditure and the mechanisms by which glucose is stored or, is released into the blood. The human clinical study using the standardized, highly purified CAE targeted weight loss via an activity on postprandial blood glucose concentration (PBGC). PBGC is the fancy term referring to the amount of sugar remaining in your blood after eating a meal (the italicized terms are synonymous). This figure varies according to the composition of the meal but in every case is accompanied by an increase in the secretion of insulin and a decrease in the synthesis of glucagon. This hormonal activity results in the decrease of blood sugar by increasing its storage as glycogen in the liver or muscles (and in the form of fat (triglycerides) in fat cells, if glycogen storage areas fill up). This is called the 'absorption phase,' as the sugar is being absorbed from the blood.

Over time (toward the end of the absorption phase or when fasting), the plasma glucose level decreases and reversal of the hormonal regulation occurs such that insulin levels drop and the secretion of glucagon increases. This activity results in the release of muscle glycogen for use as energy. High levels of glucagon will act to produce fatty acids from stored fat.

The Role of Chlorogenic Acid in CAE

Chlorogenic acids are a group of esters of varying composition. The most common of these esters is 5-caffeoylquinic acid. It is commonly called "chlorogenic acid" in research papers, but this term may also be used to refer to other esters in the mix found in CAE. Hence, for the sake of simplicity, the term chlorogenic acid (CA) will be used in this paper as a generic term for all members of the ester group.

If the results of the study are indicative, the presence of CA in the CAE increased the effectiveness of reduced GI by a significant margin. This was not an unexpected outcome. Rather, it was a reasonable and predicted result, based on the observations of a number of scientific papers describing the action of CA on a number of related parameters. One of the most important of those actions is a postprandial reduction in the absorption of glucose from the intestines. Decreased glucose absorption means less excess glucose in the blood, an eventual decrease in insulin resistance, a propensity for greater fat burning activity in liver and muscle cells, reduced fat storage and loss of body weight. The specific mode of action is an inhibitory effect on the sodium ion electrochemical gradient which draws glucose into the cells (enterocytes) lining the gut. This appears to be a dose-dependant phenomenon (in rats the effect has been as high as 80%). In a human study it was found that CA significantly attenuated the postprandial release of GIP (glucose-dependent insulinotropic polypeptide). The GIP response is directly related to the amount of glucose absorbed at the intestinal barrier; hence, a decrease in GIP reflects a decrease in glucose absorption.

Another manner in which CA decreases the blood glucose load is through the inhibition of an enzyme known as glucose-6-phosphatase (G6P). G6P plays an important role in the homeostatic control of blood sugar concentration. Present only in the liver, it is really an enzyme system and is responsible for the conversion of glucose-6-phosphate into glucose capable of passing into the general circulation. Inhibition of G6P causes a reduction in the liver's production of glucose and consequently decreases abnormally high levels of glucose in the blood. All sugars from the diet are transformed into G6P, which will be stored as glycogen because they cannot be broken down into glucose and released into the blood by G6P. Animal studies indicate that CA improves sensitivity to insulin by improving the distribution of minerals and by reducing peripheral insulin resistance.

To summarize the body of work done on chlorogenic acid, the following sequence of events will occur following its regular consumption:

A reduction in the intestinal absorption of glucose.
Inhibition of glucose-6-phosphatase (G6P).
Inhibition of the release of hepatic glucose originating from:
the diet
glycogenolyis (the creation of glucose from glycogen)
gluconeogenesis (the formation of glucose, especially by the liver, from noncarbohydrate sources, such as amino acids and the glycerol portion of fats).
Lowering of blood glucose concentration.
A decrease in the secretion of insulin and an increase in the secretion of glucagon.
Mobilization of fat reserves to supply energy required by muscles and other tissues.
The burning of free fatty acids for the production of energy in cellular energy cycles.
An Important Note About CAE Extraction

In order to produce this extract with proven weight-reducing activity, the raw material must undergo considerable processing. The desired end result is a product standardized to specific levels of chlorogenic acids and 5-caffeoylquinic acid. However, proper, safe CAE extraction requires and additional processing step: the removal of potentially harmful diterpines. Until this crucial additional processing step was accomplished (and we know of only one manufacturing who takes this important last step), we had not considered CAE suitable for long-term human consumption. Now that a diterpene-free extract is available, it has become the major weight-loss component of Formula 9™ and is exclusive to this product.

NOTE: Any compound that claims to be CAE, but which fails to remove diterpenes is unsuitable for use in humans.

CAE and Xanthines

Xanthines constitute a family of stimulants that work primarily through the central nervous system and the sympathetic division of the peripheral nervous system. They produce a release of both neurotransmitters and hormones. Two of the most important of these hormones are adrenaline and noradrenaline, which produce an almost immediate effect on vigilance and a more sustained effect on stamina. Xanthines are rapidly absorbed in the intestine (80%) and the stomach (20%). Because of their lipophilic nature, they rapidly penetrate cell membranes and easily cross the blood-brain barrier.

A good deal of the research on xanthines has shown that they exert their ergogenic properties in two ways. First, they energize the central nervous system, which results in the nearly immediate increase in mental clarity. Second, and equally important, they stimulate lipolysis in fat cells, thereby providing cellular fuel to meet the needs of people involved in prolonged physical or mental exertion, as is required in a typical day's work or play output. Lipolysis is the process whereby stored body fat is converted into forms the body uses for short term and long term energy production.

Recently, the armed forces of the United States and Canada have become seriously interested in the possible application of xanthines as a method for increasing the performance of soldiers under acute and chronic stress. When people are exposed to several stressors, mental and physical performance is substantially degraded. The military was the first to recognize the serious lack of procedures for counteracting this problem. Astute students of military history, however, would have noticed that plant materials containing xanthines have often been used by military personnel to ward off sleepiness while on guard duty and to maintain vigilance under combat situations lasting for several days without relief.

In one of the most rigorous experimental investigations of the possible role of a trimethylxanthine to offset acute stress, researchers at the U.S. Army Research Institute of Environmental Medicine, in conjunction with scientists from Tufts University and Pennington Biomedical Research Laboratory, examined whether moderate doses of this xanthine would reduce adverse effects of sleep deprivation and exposure to severe, multifactor, environmental and operational stress on mental performance. In this study, U.S. Navy Sea-Air-Land (SEAL) trainees received either placebo or xanthine capsules after 3 days of sleep deprivation and continuous exposure to other stressors, including running, lifting, paddling, swimming, calisthenics and other rigors inflicted during the appropriately named "Hell Week" period of training.

As might be expected, sleep loss and exposure to other severe stressors resulted in a profound deterioration in all aspects of cognitive function assessed. Measured against placebo, the xanthine-treated group experienced a significant improvement in visual vigilance, reaction time, repeated acquisition and self-reported fatigue and sleepiness, with the greatest effects on vigilance, reaction time and alertness. Interestingly, marksmanship, a task that could be affected by shakiness or jitteriness, was not affected by xanthine. The researchers concluded that even under the most adverse conditions, moderate doses of xanthine can improve cognitive function, including vigilance, learning, memory and mood state.

Other studies have yielded similar results. For example, in a study carried out under the Defense R&D of Canada, a group of civilian and military personnel were enlisted in a trial to examine the duration of xanthine's ergogenic effect and whether it differs between users and non-users of the substance. In this trial, patients were required to ride to exhaustion on a stationary bicycle, following consumption of 5 mg/kg of trimethylxanthine. In the end, the compound allowed the subjects to exercise for about 1/2 hour longer, and the non-users benefited slightly more than the users (about 5 minutes). Not only the duration but the magnitude of response was greater. The energizing effect achieved through xanthine ingestion has been demonstrated in several other studies.

As mentioned above, xanthines exert two primary actions that can account for the observed enhancement of mental and physical performance. First, xanthines are universally recognized for their ability to augment central nervous system function. This probably accounts for much of the immediate effect on mental clarity, learning, vigilance, etc. Second, the quick effect on the nervous system would only be expected to last for a few minutes in the absence of added fuel in the form of glucose and, indirectly, from increased free fatty acid concentration throughout the rest of the body. The extended release of xanthines in Formula 9™ means that fuel in the form of free fatty acids will be available throughout the day, thereby helping to extend for hours the positive effects on mental and physical function.

Incidentally, the usefulness of xanthines is not restricted to any particular sex or age group. Indeed, it has been shown that the elderly experience a decreased ability to mobilize fat in response to exercise. In this age group, research has found that xanthines augment fat mobilization as they do in the young, but to a lesser degree. In other words, the elderly need all the help they can get, and xanthines should be a great aid.

The presence of modest amounts of xanthine in CAE helps contribute to its overall beneficial effects in the management of weight. Formula 9 is improved even further by the addition of xanthines (primarily in the form of trimethylxanthine) from several plant sources.

Additional Elements of The Formula 9™ Blend

Complementing the patented CAE in Formula 9 is a group of ingredients designed to enhance the energy and weight-loss properties of CAE. In particular, additional trimethylxanthine has been incorporated to provide an even greater energy boost (see discussion of xanthines above). Other methylxanthines-containing plants are included to improve the overall xanthine composition of the product for an even better energy profile. Ingredients for the modification of so-called cellular second messengers are included to improve the efficiency of the fat burning (lipolytic) properties of the plant through the augmentation of catecholamine metabolism.

Formula 9™: Unsurpassed Weight Control and Energy

Formula 9 is the first of a new breed of energy and weight-control agents, designed to target overweight concerns where they start, namely the 2-hour period directly following the consumption of a meal. Formula 9 is designed to keep the sugar out of the blood and to prevent fat formation at the earliest possible stage.

In addition, Formula 9 incorporates an extra but very important component for consumers trying to lose weight. Formula 9 delivers a significant energy boost to meet the daily energy demands and encourage fat burning.

The result? Formula 9 is an extremely effective weight-loss, fat-loss and energy formula that offers consumers a superior alternative to traditional, last-generation weight control. Formula 9 does indeed set a new standard.

Formula 9 is an extremely effective weight-loss, fat-loss and energy formula that offers consumers an alternative to traditional weight control.

Other ingredients: Rice flour, magnesium stearate, cellulose and silicon dioxide.

Directions: Take with a large glass of water, two capsule with lunch and two capsules with dinner. Not to exceed 2 servings in any 8-hour period. For a significant energy boost, take 2 capsules anytime needed. Do not exceed 4 capsules per day. For maximum weight loss, this product should be taken in conjunction with a healthy eating plan as suggested by the 2005 Dietary Guidelines for Americans.

Formula 9 60 Capsule Bottle 15-30 Day Supply (using 2-4 daily)	Formula 9 1 Bottle Reg. $39.99 Sale $28.99 Formula 9 2 Bottles Reg. $79.99 Sale $57.99 Formula 9 3 Bottles Reg. $119.99 Sale $83.99 Formula 9 6 Bottles Reg. $239.99 Sale $164.99 Formula 9 12 Bottles Reg. $479.99 Sale $323.88 $26.99 each! Best Value!!

Formula 9 by Dynakor	4StarHealth.com Rated 4 out of 4 Stars!!!

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